For my latest game, an Android version of Five Field Kono, I decided that I would experiment with HTML5 and Cordova (PhoneGap).
All graphics in this game (with the exception of the opening splash screen) are generated programmatically. On launch, the program queries the screen size, orientation, and presence (or lack) of banner advertisement and then generates all the graphics to fit in the available space. I did this with Canvas. The primary benefit is that it can generate HD quality graphics at ANY screen size/resolution/orientation. As long as performance doesn’t take too much of a hit, I will try to move to this style of game development for all future releases.
I dream of the day when pixels are relegated to photographs and not much else.